The OECD Guidelines are at present one of the few mechanisms available to address the impacts of corporate misconduct. Though they can neither impose sanctions nor offer compensation, they provide a potentially valuable instrument for operationalising the “Protect, Respect, Remedy” framework developed by John Ruggie, Special Representative to the United Nations Secretary General (SRSG) on Business and Human Rights. This OECD Watch paper provides a contribution to the current international debate on business and human rights, with a specific focus on the relationship between the OECD Guidelines for Multinational Enterprises and the ‘Ruggie mandate’. The likely review of the OECD Guidelines in 2010 will provide an opportunity to strengthen human rights elements of the OECD Guidelines and contribute to the ‘operationalisation’ of the Ruggie framework.